Senior Staff Scientist (Medicinal Chemistry)

Date Posted: 09/15/2023
Req ID:33974
College/Division: College of Arts & Science
Division: Acceleration Consortium
Campus: St. George (Downtown Toronto)

Description:

The Acceleration Consortium (AC) on the College of Toronto (U of T) is main a transformative shift in scientific discovery that may speed up know-how growth and commercialization. The AC is a world group of academia, business, and authorities that leverages the ability of synthetic intelligence (AI), robotics, supplies sciences, and high-throughput chemistry to create self-driving laboratories (SDLs), additionally referred to as supplies acceleration platforms (MAPs). These autonomous labs quickly design supplies and molecules wanted for a sustainable, wholesome, and resilient future, with functions starting from renewable vitality and client electronics to medication.AC Senior Workers Scientists will advance the infield of AI-driven autonomous discovery and develop the supplies and molecules required to deal with society’s largest challenges, akin to local weather change, water air pollution, and future pandemics.

The Acceleration Consortium acquired a $200M Canadian First Analysis Excellence Grant for seven years to develop self-driving labs for chemistry and supplies, the biggest ever grant to a Canadian College. This grant will present the Acceleration Consortium with seven years of funding to execute its imaginative and prescient.

The AC is growing seven superior SDLs. These embody:

Inorganic solid-state supplies,

Natural small molecules for superior supplies,

Drug discovery with chemical probes,

Polymers for supplies science and organic functions,

Formulations for prescription drugs, client merchandise, and coatings,

Biocompatibility (organ-on-a-chip), and

Artificial scale-up of supplies and molecules.

This job posting is for a Workers Scientist place inside SDL3: Medicinal Chemistry.

Experience in a number of of the next areas is desired:

Medicinal chemistry / drug discovery with chemical probes

• • Protein biophysics / biochemistry
  • Mass spectrometry (together with affinity selection-MS)
  • Managed launch properties and processes
  • Natural synthesis of medicinal compounds / medication

AI / computational / automation experience (an asset)

• • Machine studying in life sciences
  • Robotics and automation
  • Excessive-throughput experimentation

The Senior Workers Scientists will work with a various staff of main consultants on the U of T and the College Hospital Community (UNH), together with: Dr. Cheryl Arrowsmith and Prof. Rob Batey.

The Senior Workers Scientists concerned within the AC are extremely expert and skilled researchers who will work independently to develop the AI and automation applied sciences required to construct strong and scalable self-driving labs, handle these SDLs, and design and implement analysis packages (based mostly on the route of the AC’s scientific management staff) that leverage the SDL platforms to find supplies and molecules.

Senior Workers Scientists will play a management function inside the AC analysis enterprise, set goals and instructions for a subgroup of Workers Scientists. These positions contain a major diploma of autonomy and latitude on the way to obtain the bold objectives of the AC. This function will report back to the Tutorial Director and Govt Director of the Acceleration Consortium. We’re in search of people with numerous backgrounds and experience to assist the event of self-driving labs and supplies discovery.

The parts and duties of the work embody:

SDL and Automation Growth

Working with the AC group, together with college and companions to find out the required capabilities of the SDLs to be constructed. Creating the plans for SDLs that may meet consumer necessities and designing novel devices for automated materials synthesis and characterization. Creating personalized {hardware} and Python software program packages to construct SDLs. Choice, procurement, and set up of the gear required for SDLs.

Facility Administration and Operations

Working with the division of Chemistry, Amenities and Operations, and AC analysis workers to make sure that the AC labs are absolutely operational.

• • Overseeing the exercise of the laboratory technicians servicing the labs
  • Supporting the choice, procurement, and set up of kit
  • Managing laboratory budgets
  • Scheduling and coordinating lab entry

Analysis Path

Working as a co-investigator, in partnership with the Principal Investigator, impartial administration, growth, and execution of analysis packages that leverage the AC’s SDLs and helps the analysis goals of AC college and business companions. Utilizing SDLs to synthesize and characterize giant portions of candidate molecules, calibrating theoretical fashions with experimental knowledge, predicting promising candidates with computational instruments and machine studying algorithms, and elucidating structure-property relationships of rising molecules, polymers, solid-state supplies, formulations, and so on.

Duties embody:  

• • Managing the analysis and growth tasks of AC’s business companions when applied in AC labs.
  • Creating plans that assist analysis collaborations and planning and estimating monetary assets required for packages and/or tasks.
  • Supervising the work of Workers Scientists, Software program Engineers, Analysis Associates, and Submit-doctoral Fellows.
  • Working with Product Managers to make sure analysis outcomes meet companion necessities.
  • Monitoring and reporting on related analysis exercise to the Tutorial Director and Govt Director.
  • Selling AC’s analysis capability, together with delivering displays at conferences.
  • Collaboration within the preparation and submission of analysis proposals to granting businesses and progress reporting. 
  • Making ready manuscripts for submission to look evaluate publications/journals and stewarding them by way of the method.

Different

• Supporting consulting providers associated to the appliance of SDLs for supplies discovery for the AC’s companions.
• Assist research-focused occasions akin to Annual Symposium

The College of Toronto is strongly dedicated to range inside its group and particularly welcomes functions from racialized individuals / individuals of color, girls, Indigenous / Aboriginal Folks of North America, individuals with disabilities, LGBTQ individuals, and others who could contribute to the additional diversification of concepts.

MINIMUM QUALIFICATIONS:

Schooling – Ph.D. in chemistry, supplies science, life sciences, physics, engineering, robotics, pc science, or associated self-discipline

Expertise

• Over 10 years of expertise in analysis and growth 
• Expertise working intently with a Principal Investigator or as a Principal Investigator, or as a Challenge Director with tasks of managing, growing and executing a serious analysis challenge
• Sturdy expertise and professional information of AI and automation.
• Expertise with the event of self-driving laboratories and overseeing the actions of a lab
• Expertise working with business companions and on business lead analysis and growth tasks
• Sturdy expertise presenting analysis at tutorial conferences
• Expertise managing analysis workers.
• Expertise managing a laboratory funds and procuring gear
• Will need to have a powerful scholarly publication report

Expertise

• Sturdy in speaking successfully and effectively in oral and written English
• Collegial in working with staff members and collaborators
• Capability to work independently

Different  

Demonstrated success within the writing and preparation of manuscripts, displays, studies, briefs, and scientific abstracts and manuscripts for peer-reviewed journals.

Closing Date: 12/31/2023, 11:59PM ET
Worker Group: Analysis Affiliate
Appointment Kind: Grant – Persevering with
Schedule: Full-Time
Pay Scale Group & Hiring Zone: 150K – 180K (wage shall be assessed based mostly on expertise and experince)
Job Class: Analysis Administration & Educating