Research Assistant/Tech 5 – Lange

University of British Columbia

Staff – Non Union

Job Category

Non Union Technicians and Research Assistants

Job Profile

Non Union Salaried – Research Assistant /Technician 5

Job Title

Research Assistant/Tech 5 – Lange


Lange Laboratory Department of Pathology and Laboratory Medicine Faculty of Medicine

Compensation Range

$5,322.75 – $6,096.25 CAD Monthly

Posting End Date

March 1, 2023

Note: Applications will be accepted until 11:59 PM on the day prior to the Posting End Date above.
Job End Date

Mar 1, 2024

This position is located within a health-care facility. Therefore, this positions requires successful verification of full vaccination against Covid-19 provided prior to the start date, as required by the provincial health mandate.
The anticipated start date for this position is March 1, 2023. The term is for one year with the possibility of extension.
In your application please include (1) a cover letter, and (2) a CV or resume.
At UBC, we believe that attracting and sustaining a diverse workforce is key to the successful pursuit of excellence in research, innovation, and learning for all faculty, staff and students. Our commitment to employment equity helps achieve inclusion and fairness, brings rich diversity to UBC as a workplace, and creates the necessary conditions for a rewarding career.
Job Summary
The Lange laboratory for translational proteomics at the University of British Columbia and BC Children’s Hospital investigates innovative approaches to precision medicine for childhood cancer patients.
We strive to develop new diagnostic and therapeutic approaches to detect and treat children suffering from cancer earlier, better and with reduced impact on their life. To reach this goal, we use mass spectrometry-based proteomics; biochemistry; cell biology; and molecular biology approaches to study protein function and modification in childhood cancers and develop precision medicine pipelines. We are highly collaborative at the local, national and international levels. Our work has and continues to advance understanding of protein modification, improve proteomic investigation on small patient biopsies and changed patient care.
We are seeking an exceptional research technician and data analyst to pursue this goal together with us and join our dynamic translational research team and activities to advance precision oncology for kids with cancer.
Your main responsibility will be the analysis and biological interpretation of proteomics data. You will provide reports to investigators and collaborators and be directly involved in national precision medicine initiatives such as PROFYLE and the Canadian Pediatric Cancer Consortium and work with scientists and clinicians across the country. You will also ensure optimal performance of the group’s mass spectrometers and advance automation of sample handling and processing. You will perform proteomics sample preparation, and method development and will independently design and conduct experiments to improve technology and investigate protein function and modification in cancer.
You have strong analytical and organizational skills and will bring advanced experience in proteomics, mass spectrometry and biochemistry. You love statistical analysis and powerful visualization of biological data and strive to apply and advance your expertise to support a team’s efforts.
We offer a high degree of flexibility, an attractive compensation package including health benefits and opportunities for ongoing professional development.
Organizational Status
The successful candidate will report to the principal investigator.

Work Performed

  • Independently maintain, calibrate, operate, and troubleshoot problems with infrastructure including liquid-chromatography tandem mass spectrometry systems and liquid handlers
  • Conduct protein extraction and LC-MS/MS analysis for cell models, animal models and patient biopsies
  • Quantitative analysis and biological interpretation of proteome data
  • Generate reports (quality control and performance metrics, pathway level characterization of single patients and cohorts, study overviews, focused on a research question, …)
  • Improve proteomic capabilities (e.g. introduce automation and develop methods and SOPs for posttranslational modifications and targeted assay)
  • Independently develop new analytical techniques and methodologies.
  • Independently conduct biochemical and cell culture experiments
  • Supervise graduate students and postdoctoral fellows with their research projects. Provide technical expertise on project development and experimental design, provide expertise on data interpretation and analysis
  • Keep up-to-date on data analysis methodologies and learn to use new data analysis software
  • Provide significant contributions to the preparation of research publications and grant and research ethics applications.
  • Collaborate and act as a consultant with internal and external researchers on sample processing, experimental design and data analysis of proteomic studies.
  • Participate in meetings related to technical, scientific and organizational aspects of the project
  • Other duties as required.
Consequence of Error/Judgement
Errors may result in the permanent loss of irreplaceable specimens, loss of thousands of dollars of material and/or damage to equipment. Loss of research results could result in the failure of a funded project and put in jeopardy any future funding and the international reputation of the Laboratory and the Institute.

Supervision Received
Works under minimum supervision, receiving specific instructions only on unusual problems or when receiving new projects outlines from the principal investigator.

Supervision Given
Train students and junior lab staff, provide input on staff/co-op student selection and performance evaluation.

Minimum Qualifications
University degree in relevant discipline or completion of a technical program and a minimum five years of related experience or an equivalent combination of education and experience. Some positions may require a graduate degree.

  • Willingness to respect diverse perspectives, including perspectives in conflict with one’s own
  • Demonstrates a commitment to enhancing one’s own awareness, knowledge, and skills related to equity, diversity, and inclusion
Preferred Qualifications
  • PhD degree in a relevant discipline.
  • All relevant UBC safety courses including biosafety and chemical safety are required but can be completed during orientation.
  • Demonstrated ability to work independently and communicate effectively with faculty, staff, trainees, and collaborators.
  • Exceptional attention to detail
  • Advanced knowledge in mass spectrometry operation and maintenance
  • Advanced knowledge in proteomic sample preparation
  • Advanced knowledge in cell biology and biochemical research methods
  • Advanced knowledge in statistical analysis and visualization for protein or RNA data
  • Advanced knowledge in cancer biology and interpretation or quantitative protein or RNA data
  • Experience in laboratory management
  • Strong organizational skills and ability to work in a team-oriented environment.
  • Good English verbal and oral communication skills.
We Offer:
  • A dynamic and diverse work environment.
  • An attractive compensation package including health benefits
  • The opportunity to take the lead in building a new mass spectrometry facility at the BC Children’s Hospital Research Institute.
  • The opportunity to work with and learn from world experts in proteomics at UBC, BC Cancer Research Centre and the BCCHRI.
  • The opportunity to conduct research and develop new methods.
  • Plentiful opportunities to advance your skills and take on new roles.

Apply Now
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