Formulation Scientist

Avro Life Science

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About us

Avro Life Science is building the next generation of therapeutics for the skin, utilizing our passive delivery technology to pioneer the field of nucleic acid based dermatology. Our ionic liquid platform enables the delivery of complex and charged macromolecules into the skin, facilitating the localized delivery of siRNAs, mRNAs, ASOs and CRISPR-RNP payloads, among many others.

We’re working with some of the world’s leading experts in skin biology, nucleic acid chemistry, formulation chemistry, and partnering with leading biopharma companies, and research institutions to bring new drugs to market for some of the most prevalent and undertreated skin disorders in existence.

We’re a young, mission driven team of 12 chemists, biologists and engineers from industry and academia with extensive experience in the development and scale-up of novel polymers, drugs, devices, and more.

Position Summary

The ideal candidate for this position will have experience in formulation chemistry, skin penetration enhancers and the development of nanocarriers for drug delivery (micelles, liposomes, niosomes, etc) along with the design of novel materials for manipulating biological membranes (LNPs, skin penetrating peptides, ionic liquids, organogels, gemini surfactants, etc). The ideal candidate will also have a strong understanding of skin biology and associated pathologies, and exposure to the use of nucleic acid therapeutics.

You will:

  • Review known literature to develop strategies for the formulation of novel passive topical delivery systems for small molecules and biologics
  • Work with the senior scientific team to develop novel formulations for the passive topical delivery of large molecules ( >500Da)
  • Develop experiments for verifying the stability, and intracellular delivery of nucleic acid based therapeutics (gel electrophoresis, circular dichroism, ELISA, etc)
  • Design experiments for identifying mechanisms of dermal penetration or disruption and verifying the dermal delivery of complex therapeutics (siRNA, ASO, pDNA, CRISPR etc)
  • Work with the senior scientific team to develop and further validate in-house ex-vivo testing methods to develop robust internal formulation screening methods for formulation development
  • Cooperate with academic institutions, external CROs and partners to develop and carry out protocols for in-vivo testing of dermal drug delivery systems, including hands-on work with small animal models
  • Act as an analytical SME for internal product development using traditional and advanced analytical techniques including but not limited to UV-Vis, HPLC, GC, GPC, NMR, LC-MS, GC-MS, XRD, Raman, FTIR, Microscopy and SEM.
  • Collaborate with external partners during technology transfers of analytical methods, CMC, clinical batch testing and stability testing
  • Scale products in-house and at local manufacturing sites for clinical and commercial batch sizes
  • Provide guidance and supervision where necessary to co-op students and research associates
  • Communicate results, discoveries, etc to executive team and research team in weekly meetings

Requirements

  • PhD in Pharmaceutical Sciences, Biochemistry, Chemistry, Biology, Chemical Engineering, Materials Engineering, Nanotechnology Engineering, Bioengineering or related disciplines with 3+ years of experience
  • Experience in formulation development of topical or transdermal drug delivery systems is highly recommended
  • Experience in formulation chemistry and the development of nanocarriers for drug delivery (micelles, liposomes, niosomes, etc) along with the design of novel materials for manipulating biological membranes (LNPs, skin penetrating peptides, ionic liquids, organogels, gemini surfactants, etc) is a strong asset
  • Prior experience working with nucleic acid or other complex biologic payloads is a strong asset
  • A background in pathology (especially skin related) is a significant asset in identifying biological assets
  • Knowledge of physiology, pharmacology, pharmacodynamics and pharmacokinetics is an asset, but not necessary
  • Experience with 505(b)(2) NDA development and filing requirements is an asset, but not necessary
  • Experience with current Good Manufacturing Practices (cGMP) and Good Laboratory Practices (GLP) is an asset, but not necessary
  • Demonstrated verbal and scientific written skills in communicating technical and regulatory information.

Job Type: Full-time

Salary: $49,566.00-$80,000.00 per year

Benefits:

  • Casual dress
  • Company events
  • Dental care
  • Disability insurance
  • Employee stock purchase plan
  • Extended health care
  • Flexible schedule
  • Life insurance
  • On-site gym
  • On-site parking
  • Paid time off
  • Vision care

Schedule:

  • Monday to Friday

Supplemental pay types:

  • Bonus pay

COVID-19 considerations:
Masks are mandatory at the office, lab has 5x the recommended number of air changes per hour, and social distancing measures are in effect at desks and in work spaces. Rapid tests are also available on site.

Education:

  • Master’s Degree (preferred)

Experience:

  • formulation development: 3 years (preferred)
  • Laboratory: 5 years (preferred)

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